Funnily enough, on offense, the Denver Broncos have scored one, two, and three touchdowns in Weeks 1, 2, 3, respectively. It is safe to say that offensive coordinator Davis Webb is getting more comfortable calling the plays, as the touchdown production has increased each week.
And with how banged up the San Francisco 49ers are, this could be the game where the offense does hit its stride, but that's only one side of the ball.
The 49ers are 3-0 for a reason, so the Broncos will have their hands full. Let's dive into our three weekly bold predictions for Week 4.
Denver Broncos bold predictions for Week 4 against the 49ers
Bo Nix finishes with a passer rating of at least 95
Passer rating isn't the best statistic to look at when evaluating quarterback play, but in many instances, a higher passer rating can mean that the QB played well. In Week 4, Nix will see his passer rating hit at lest 95 for the second time this season.
The 49ers have a slew of defensive players not playing in this one and some who are questionable for Week 4. This entire team is simply enduring a ton of injuries yet again.
#49ers game status report for the following players β¬οΈ
β RowdyNinerTalk (@RowdyNinerTalk) October 3, 2026
OUT π«
DE Nick Bosa (calf)
DT James Thompson Jr. (ankle)
Questionable β
WR Mike Evans (rib)
DE Keion White (hamstring)
LB Dre Greenlaw (quad)
Jaden Dugger (shoulder)#FTTB pic.twitter.com/zIXW0p2m5t
The 49ers also just hosted the Arizona Cardinals, and Cardinals QB Jacoby Brissett finished with 280 yards, a pair of touchdowns, and a completion percentage of 73.1. This is a defense that Nix and the offense should be able to move the ball against through the air, and we'll see that happen efficiently in Week 4.
Rushing offense has their highest output of the season
How about the rushing offense, too? The Broncos have the personnel to field a solid rushing attack, as J.K. Dobbins and RJ Harvey have both shown flashes, and Harvey wasn't even on the injury report this week, so there is reason to believe he's 100 percent, or close to it.
The Broncos offensive line is largely looked at as being one of the better units in the league. And while the rushing attack hasn't been great this year, there are some indicators that it's ready to explode:
Negative Run % through Week 3
β SFdata9ersππ (@sfdata9ers) October 2, 2026
1. SF
2. WAS
3. CAR
...
30. NYJ
31. LV
32. GB (by a mile) pic.twitter.com/RdUdbaeH5e
The Broncos have the fourth-best rate of the league of negative run percentage, and their running backs have the third-best rate in the league in terms of not being contacted at or behind the line of scrimmage:
Which RBs are getting met in the backfield the most
β SFdata9ersππ (@sfdata9ers) October 2, 2026
Data: @FantasyPtsData pic.twitter.com/A4HUrzShFX
It could only be a matter of time before we see this run game getting going. Week 4 could present the game where it does.
Broncos again win by one score
Because in typical Broncos fashion, this has to happen, right? The offense has a really solid chance in front of them to get going, but the defense may struggle to stop a unit that feels rather unstoppable this year. 49ers QB Brock Purdy is playing at an MVP level, and while their wide receiver room is banged up, Christian McCaffrey and George Kittle are always creating issues.
Denver and San Francisco's Week 4 showdown will come down to eight points or fewer, and as the Broncos do, they'll win it by a small margin.
