3) More Injuries
This scenario is by far the worst. The Broncos have already been struck by injures before week one even officially began. The Broncos are starting down starting corner K'Waun Williams, who landed on the IR before the season began. Additionally, WR Jerry Jeudy, presumably the team's top wideout, starts the season with his health in question after a hamstring injury. Beyond the current injuries, the Broncos ended the year with Garett Bolles, Lloyd Cushenberry, Javonte Williams, and Randy Gregory on the IR, amongst other players who are back with the Broncos.
Beyond the immediate impact on the Week 1 game, a handful of Broncos injuries would work towards derailing the Broncos' season. The Broncos would obviously prefer their depth not get tested, but at certain positions, such as both the offensive and defensive lines, their depth is shaping up to already be a major concern. If the Broncos suffer substantial injuries on either line, the season could start to get away from them, such as it did last year after key injuries to Gregory and Bolles. A handful of key injuries in Week 1 is the ultimate worst-case scenario for the Broncos and one they want to avoid at all costs.